Involvement of a Rac Activator, P-Rex1, in Neurotrophin-Derived Signaling and Neuronal Migration
نویسندگان
چکیده
منابع مشابه
Involvement of a Rac activator,P-Rex1, in neurotrophin-derived signaling and neuronal migration.
Rho-family GTPases play key roles in regulating cytoskeletal reorganization, contributing to many aspects of nervous system development. Their activities are known to be regulated by guanine nucleotide exchange factors (GEFs), in response to various extracellular cues. P-Rex1, a GEF for Rac, has been mainly investigated in neutrophils, in which this molecule contributes to reactive oxygen speci...
متن کاملPI3K regulates MEK/ERK signaling in breast cancer via the Rac-GEF, P-Rex1.
The PI3K pathway is genetically altered in excess of 70% of breast cancers, largely through PIK3CA mutation and HER2 amplification. Preclinical studies have suggested that these subsets of breast cancers are particularly sensitive to PI3K inhibitors; however, the reasons for this heightened sensitivity are mainly unknown. We investigated the signaling effects of PI3K inhibition in PIK3CA mutant...
متن کاملIdentification of the Rac-GEF P-Rex1 as an essential mediator of ErbB signaling in breast cancer.
While the small GTPase Rac1 and its effectors are well-established mediators of mitogenic and motile signaling by tyrosine kinase receptors and have been implicated in breast tumorigenesis, little is known regarding the exchange factors (Rac-GEFs) that mediate ErbB receptor responses. Here, we identify the PIP(3)-Gβγ-dependent Rac-GEF P-Rex1 as an essential mediator of Rac1 activation, motility...
متن کاملRac Activation: P-Rex1 — A Convergence Point for PIP3 and Gβγ?
Small GTPases of the Rho family regulate a vast spectrum of functions in eukaryotic cells, from cyto-skeletal rearrangements to vesicle transport to transcriptional regulation. Rho GTPases act as molecular switches, cycling between an ‘inactive’ GDP-bound form and an ‘active’ GTP-bound form. Activation is accomplished by guanine-nucleotide exchange factors (GEFs) which catalyze GDP dissociation...
متن کاملP-Rex1, a PtdIns(3,4,5)P3- and Gβγ-Regulated Guanine-Nucleotide Exchange Factor for Rac
typically possess a PH domain that can bind the lipid and drive translocation of the host protein to the site of PtdIns(3,4,5)P 3 accumulation Summary in the plasma membrane (not all PH domains bind PtdIns(3,4,5)P 3 ; Lemmon and Ferguson, 2000). In many Rac, a member of the Rho family of monomeric cells, type 1 PI3Ks have been shown to be necessary GTPases, is an integrator of intracellular sig...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Neuroscience
سال: 2005
ISSN: 0270-6474,1529-2401
DOI: 10.1523/jneurosci.4955-04.2005